NeuroDev
The NeuroDev team is led by Vincent El Ghouzzi and Nicolas de Roux, and combines experts in experimental and clinical research in the field of neurodevelopmental disorders.

NeuroDev
Brain development is associated with a series of developmental sequences including the proliferation, migration and differentiation of neurons and glial cells. In humans, it is a particularly long process starting in early embryonic life and lasting up to the end of adolescence.
These sequences of events are not fully programmed but rely on developmental checkpoints. Altering these sequences through genetic mutations or environmental insults leads to phenotypic alterations and lifelong neurological and psychiatric disorders, termed Neurodevelopmental Disorders (NDDs). Later in the lifespan, neurodegenerative diseases could also result from perturbations in late developmental sequences and/or the impairment of brain maintenance.
The complexity of human brain development renders human monogenic genetic disorders unique models to decipher the key mechanisms involved. Our work focuses on inherited NDDs affecting:
- antenatal or postnatal brain growth (microcephalies),
- white matter development (leukodystrophies),
- rare neuronal disorders characterized by a pubertal defect.
Our objective is to approach neuronal and glial cell dysfunctions in NDDs from a unique integrative viewpoint using five complementary approaches centered on in vivo and cellular NDD models and their therapy:
(1) deciphering the role of energy pathways in the fate of neural progenitors,
(2) understanding the role of centrosome and Golgi apparatus defects in brain cell division and maturation,
(3) analyzing the link between membrane trafficking defects and postnatal neuroendocrine maturation,
(4) studying mitochondrial dysfunction in appropriate mouse models of NDDs, in order to design original therapies,
(5) developing integrative genomic diagnostic tools for the identification of common pathways involved in NDDs that are suitable for therapeutic targeting.
Contacts
Vincent El Ghouzzi
UMR1141 Inserm – Paris Cité University
Hôpital Robert Debré
48 boulevard Sérurier
75019 Paris, France
vincent.elghouzzi@inserm.fr
Nicolas de Roux
Service de Biochimie-Hormonologie
et UMR Inserm 1141
Hôpital Robert Debré
48 boulevard Sérurier
75 019 Paris
nicolas.deroux@inserm.fr
Mitochondries
& NDD
Brain development disorders
Puberty
diseases
Integrative genomics
Microcephaly
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New Golgipathy identified in NeuroDev team
The NeuroDev team publishes an article in Life Science Alliance [1] identifying the first human pathogenic variant of GORASP1, the gene encoding the Golgi stacking protein GRASP65, and demonstrating its consequences on glycosylation and mitotic progression. [1] S....

Post-doc opportunity (1-2 years) within the group “Mitochondria and NDD” in the NeuroDev team
POSITION DESCRIPTION Postdoctoral position in the field of Neurosciences Type of contract: temporary position (CDD) Contract/project period: 1-2 years Expected date of employment: 1.04.2025 Proportion of work: 100% Workplace: Université Paris Cité, Inserm,...

Advancing psychiatry through Sleep and Chronobiology research
The “Mood” research axis of the SleepCmd team is dedicated to understanding the intricate links between sleep, circadian rhythms, and mood disorders such as depression, bipolar disorder, seasonal affective disorder, and suicide. Using state-of-the-art methods, the...

Job opportunity within The Integrative Genomics in Neurodevelopment group
The Integrative Genomics in Neurodevelopment group is seeking a highly motivated post-doctoral researcher. Check out the opportunity here: Post-doc researcher position in Computational Biology