Team SleepCmd, in collaboration with team NeuroDev (Dr. Andrée Delahaye), receive support from the CCHS Foundation in 2022 to study the genetic dysregulations that could be associated with Congenital Central Hypoventilation Syndrome (CCHS).
Members of the SleepCmd and NeuroDev teams involved in the project
From left to right: Dr. Jorge Gallego, Eleonore Sizun, Dr. Nelina Ramanantsoa, Maud Ringot, Dr. Andrée Delahaye, Boris Matrot, Pr. Stéphane Dauger and Thomas Bourgeois.
© NeuroDiderot
Research project
We propose to analyse the respiratory function in mice carrying the PHOX2B +7Ala mutation which reproduces the main symptoms of CCHS: apneas, hypoventilation and lack of ventilatory response to CO2. This mouse model has shown that the PHOX2B +7Ala mutation causes gene deregulations in two brainstem regions involved in respiratory control. The team hopes to identify pharmacological treatments capable of regulating gene expression and possibly improving the respiratory function of the animals.
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Workshop Technical facility Neurodiderot “Flow cytometry, from conventional to spectral great prospects with the Sony ID7000” (V. Faivre) Thruday 28th may 2026 11:00 AM
Flow cytometry is a powerful quantitative technique for analyzing cell phenotypes or certain microparticles. This workshop will introduce you to the basics of conventional cytometry, then compare this technology to spectral cytometry, an innovation that appeared on...
Conference Postponed Alexandra Benchoua from I-Stem : Human pluripotent stem cell models for high-throughput screening of therapeutic molecules and precision medicine in neurodevelopmental disorders.
Meeting Room 6th floor Bingen Building and Visio https://u-paris.zoom.us/j/84730677369?pwd=AFdhdI6alNWLbXub7sM1DJ33yUIOYN.1 - Summary séminaire A-Benchoua _27-nov-2025 english
Scientific conference Thursday, April 2nd 2026 (11/00 AM) by Melody Atkins: Primary cilium-elicited signals control the polarity of migrating neurons
20260402 séminaire Melody Atkins english Meeting Room 6th floor Bingen Building and Visio https://u-paris.zoom.us/j/84730677369?pwd=AFdhdI6alNWLbXub7sM1DJ33yUIOYN.1
Conference Thursday, January 22, 2026, 11:00 AM by Xavier Leinekugel from the Institut de Neurobiologie de la Méditerranée (INMED), Marseille : Potential consequences of altered maturation of hippocampal perisomatic inhibition on cognitive development and neurodevelopmental disorders
20260122 Xavier LEINEKUGEL english