Team SleepCmd, in collaboration with team NeuroDev (Dr. Andrée Delahaye), receive support from the CCHS Foundation in 2022 to study the genetic dysregulations that could be associated with Congenital Central Hypoventilation Syndrome (CCHS).
Members of the SleepCmd and NeuroDev teams involved in the project
From left to right: Dr. Jorge Gallego, Eleonore Sizun, Dr. Nelina Ramanantsoa, Maud Ringot, Dr. Andrée Delahaye, Boris Matrot, Pr. Stéphane Dauger and Thomas Bourgeois.
© NeuroDiderot
Research project
We propose to analyse the respiratory function in mice carrying the PHOX2B +7Ala mutation which reproduces the main symptoms of CCHS: apneas, hypoventilation and lack of ventilatory response to CO2. This mouse model has shown that the PHOX2B +7Ala mutation causes gene deregulations in two brainstem regions involved in respiratory control. The team hopes to identify pharmacological treatments capable of regulating gene expression and possibly improving the respiratory function of the animals.
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New Golgipathy identified in NeuroDev team
The NeuroDev team publishes an article in Life Science Alliance [1] identifying the first human pathogenic variant of GORASP1, the gene encoding the Golgi stacking protein GRASP65, and demonstrating its consequences on glycosylation and mitotic progression. [1] S....
Post-doc opportunity (1-2 years) within the group “Mitochondria and NDD” in the NeuroDev team
POSITION DESCRIPTION Postdoctoral position in the field of Neurosciences Type of contract: temporary position (CDD) Contract/project period: 1-2 years Expected date of employment: 1.04.2025 Proportion of work: 100% Workplace: Université Paris Cité, Inserm,...
Advancing psychiatry through Sleep and Chronobiology research
The “Mood” research axis of the SleepCmd team is dedicated to understanding the intricate links between sleep, circadian rhythms, and mood disorders such as depression, bipolar disorder, seasonal affective disorder, and suicide. Using state-of-the-art methods, the...
Job opportunity within The Integrative Genomics in Neurodevelopment group
The Integrative Genomics in Neurodevelopment group is seeking a highly motivated post-doctoral researcher. Check out the opportunity here: Post-doc researcher position in Computational Biology