Team SleepCmd, in collaboration with team NeuroDev (Dr. Andrée Delahaye), receive support from the CCHS Foundation in 2022 to study the genetic dysregulations that could be associated with Congenital Central Hypoventilation Syndrome (CCHS).
Members of the SleepCmd and NeuroDev teams involved in the project
From left to right: Dr. Jorge Gallego, Eleonore Sizun, Dr. Nelina Ramanantsoa, Maud Ringot, Dr. Andrée Delahaye, Boris Matrot, Pr. Stéphane Dauger and Thomas Bourgeois.
© NeuroDiderot
Research project
We propose to analyse the respiratory function in mice carrying the PHOX2B +7Ala mutation which reproduces the main symptoms of CCHS: apneas, hypoventilation and lack of ventilatory response to CO2. This mouse model has shown that the PHOX2B +7Ala mutation causes gene deregulations in two brainstem regions involved in respiratory control. The team hopes to identify pharmacological treatments capable of regulating gene expression and possibly improving the respiratory function of the animals.
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Conference Thursday, January 22, 2026, 11:00 AM by Xavier Leinekugel from the Institut de Biologie de la Méditérannée (INMED), Marseille : Potential consequences of altered maturation of hippocampal perisomatic inhibition on cognitive development and neurodevelopmental disorders
20260122 Xavier LEINEKUGEL english
Conference Thursday, February 12 2026, 2PM (zoom) by Pr Raul Chavez-Valdez from Baltimore : Synaptic Plasticity following Neonatal Hypoxic-Ischemic Brain Injury
20260212 séminaire Raul Chavez english
Conference February 19, 2026, 11:00 AM by Dr Clément Apelian from PRHySME : Hypnosis beyond fantasy – basic science challenges and clinical relevance
20260219 séminaire Clément Alepian english
Conference April 16th, 2026, 11:00 AM by Alexandra Benchoua from I-Stem : Human pluripotent stem cell models for high-throughput screening of therapeutic molecules and precision medicine in neurodevelopmental disorders.
20260416 séminaire A-Benchoua english