HumBO is a hiPSC core facility hosted by Inserm and Université Paris Cité dedicated to the study of normal and pathological human neurodevelopment using brain organoids.

The HumBO facility of the NeuroDiderot UMR1141 research unit uses the technology of human induced pluripotent stem cells (hiPS) in order to model normal and pathological human brain development and to generate neural progenitors, postmitotic neurons and glial cells in monolayer cultures (2D) or within spheroids and organoids (3D).

© Inserm Umr1141

With almost 90 billions neurons, the human brain fundamentally differs from that of other species not only because of its size and the high number of its neuronal connections, but also through the tremendous expansion of its cortex, the kind of progenitors involved in its growth, the time required to achieve its expansion and maturation and the activation of human-specific genes. Key steps of brain development are critical to the cognitive outcome of the future child and constitute potential windows of vulnerability targeted either by pathogens or by genetic mutations.



HumBO – NeuroDiderot
Inserm UMR1141
Hôpital Robert Debré
48 Bd Sérurier
75019 Paris, France

Culture, maintenance & hiPSC lines Characterization

Expertise & Service


Team & Publications

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Sleep2Develop research program

Sleep2Develop research program

The Sleep2Develop program investigates the role of sleep as a promotor of neurodevelopment and identifies the sleep determinants of childhood development. This is rephrased as Sleep(to)Develop? or Sleep(to)Develop! Our sleep research combines clinical and...

Job opportunity

Job opportunity

NemoClinics platform is hiring an engineer. Check out the opportunity here: U 1141 -Ingénieur-e en expérimentation et instrumentation biologiques- CDD 2023 Read more

Research program on CCHS

Research program on CCHS

CCHS is a disease characterized by a congenital impairment of the central control of breathing, associated with dysfunctions of the autonomic nervous system (ANS) (Gallego, 2012). At birth, patients have severe and persistent hypoventilation during sleep and a...