Putative pathophysiology of obstructive apneas in Ondine syndrome
Monosynaptic or polysynaptic projections of Phox2b neurons from the NTS or RTN to the 12N may be required for upper airway permeabilitý during sleep. 7N = facial nucleus; 12N = hypoglossal nucleus; AP = area postrema; NTS = nucleus of the tractus solitarius: RTN = retro-trapezoid nucleus. Adapted from Amorim et al. AJRCCM 2021.
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The Sleep2Develop program investigates the role of sleep as a promotor of neurodevelopment and identifies the sleep determinants of childhood development. This is rephrased as Sleep(to)Develop? or Sleep(to)Develop! Our sleep research combines clinical and...
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CCHS is a disease characterized by a congenital impairment of the central control of breathing, associated with dysfunctions of the autonomic nervous system (ANS) (Gallego, 2012). At birth, patients have severe and persistent hypoventilation during sleep and a...