My research aims to decipher the mechanisms underlying gene – environment interactions in neurodevelopmental disorders. I specifically investigate neuron – microglia interactions, with a focus on how microglia, the resident immune cells of the central nervous system, shape neuronal development, connectivity, and function. As a critical interface between environmental signals and brain homeostasis, microglia play a key role in sculpting neuronal physiology throughout development.
I have a particular interest in Warburg Micro syndrome, a rare genetic disorder caused by defects in Rab protein signaling pathways, which are essential regulators of vesicular and membrane trafficking. Through close collaboration with clinical partners, I develop translational research programs aimed at bridging fundamental discoveries with clinically relevant applications.
To address these questions, I employ a range of experimental models, including human fetal tissues and induced pluripotent stem cells to model neurodevelopmental disorders and better understand their underlying pathophysiological mechanisms. My work is grounded in strong expertise in neuronal physiology, combining patch-clamp recording and calcium imaging.
This integrative approach enables the development of innovative research strategies to better understand how neuron–microglia interactions contribute to neural network dysfunction and may drive disease severity and progression in neurodevelopmental disorders.