HumBO
HumBO is a hiPSC core facility hosted by Inserm and Université Paris Cité dedicated to the study of normal and pathological human neurodevelopment using brain organoids.
The HumBO facility of the NeuroDiderot UMR1141 research unit uses the technology of human induced pluripotent stem cells (hiPS) in order to model normal and pathological human brain development and to generate neural progenitors, postmitotic neurons and glial cells in monolayer cultures (2D) or within spheroids and organoids (3D).
© Inserm Umr1141
With almost 90 billions neurons, the human brain fundamentally differs from that of other species not only because of its size and the high number of its neuronal connections, but also through the tremendous expansion of its cortex, the kind of progenitors involved in its growth, the time required to achieve its expansion and maturation and the activation of human-specific genes. Key steps of brain development are critical to the cognitive outcome of the future child and constitute potential windows of vulnerability targeted either by pathogens or by genetic mutations.
Contact
HumBO – NeuroDiderot
Inserm UMR1141
Hôpital Robert Debré
48 Bd Sérurier
75019 Paris, France
humbo.neurodiderot@inserm.fr
Culture, maintenance & hiPSC lines Characterization
Expertise & Service
Equipment
Team & Publications
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Workshop Technical facility Neurodiderot “Flow cytometry, from conventional to spectral great prospects with the Sony ID7000” (V. Faivre) Thruday 28th may 2026 11:00 AM
Flow cytometry is a powerful quantitative technique for analyzing cell phenotypes or certain microparticles. This workshop will introduce you to the basics of conventional cytometry, then compare this technology to spectral cytometry, an innovation that appeared on...
Conference April 16th, 2026, 11:00 AM by Alexandra Benchoua from I-Stem : Human pluripotent stem cell models for high-throughput screening of therapeutic molecules and precision medicine in neurodevelopmental disorders.
Meeting Room 6th floor Bingen Building and Visio https://u-paris.zoom.us/j/84730677369?pwd=AFdhdI6alNWLbXub7sM1DJ33yUIOYN.1 - Summary séminaire A-Benchoua _27-nov-2025 english
Scientific conference Thursday, April 2nd 2026 (11/00 AM) by Melody Atkins: Primary cilium-elicited signals control the polarity of migrating neurons
20260402 séminaire Melody Atkins english Meeting Room 6th floor Bingen Building and Visio https://u-paris.zoom.us/j/84730677369?pwd=AFdhdI6alNWLbXub7sM1DJ33yUIOYN.1
Conference Thursday, January 22, 2026, 11:00 AM by Xavier Leinekugel from the Institut de Neurobiologie de la Méditerranée (INMED), Marseille : Potential consequences of altered maturation of hippocampal perisomatic inhibition on cognitive development and neurodevelopmental disorders
20260122 Xavier LEINEKUGEL english