NeuroKines
Glial homeostasis, neuroinflammation and neuroprotection
Pre-, peri- or post-natal cerebral lesions, caused by intrinsic (cerebrovascular accidents, tumors, etc.) or extrinsic factors (fetal or maternal infections and immune activation, head trauma, etc.) lead to severe neurological deficits such as motor, sensory or cognitive defects at the origin of communication and behavior disorders. The NeuroKines team seeks to better understand the cellular mechanisms and the role of immunity and metabolism involved in the genesis of neurological lesions during brain development in order to identify new predictive diagnostic biomarkers and therapeutic targets. The candidate molecules are tested on various in vitro, in vivo models and pediatrics cohorts, reproducing pediatric neuropathological processes, with the aim of transferring the most promising neuroprotection strategies towards clinical trials.
The NeuroKines team is made up of 6 independent groups with complementary themes and led by Pierre Gressens and Juliette Van Steenwinckel (G1), Olivier Baud (G2), Stéphane Auvin and Pascal Dournaud (G3), Nadia Soussi-Yanicostas (G4), Malgorzata Rak (G5) and Mireille Laforge (G6).
KEY WORDS: Prematurity, Epilepsy, Autism, Cognitive deficits, Neuroinflammation, Infections, Immune activation, Immune response, Immunometabolism, Energy metabolism
Roles of microglia and strategies of neuroprotection
Microglia and epilepsy in the zebrafish
Prevention of perinatal neuroinflammation
Physiopathology and therapy of mitochondrial diseases
Neuroinflammation and neurotransmission
Immunometabolism and inflammation
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Job opportunity within The Integrative Genomics in Neurodevelopment group
The Integrative Genomics in Neurodevelopment group is seeking a highly motivated post-doctoral researcher. Check out the opportunity here: Post-doc researcher position in Computational Biology
Sleep2Develop research program
The Sleep2Develop program investigates the role of sleep as a promotor of neurodevelopment and identifies the sleep determinants of childhood development. This is rephrased as Sleep(to)Develop? or Sleep(to)Develop! Our sleep research combines clinical and...
Job opportunity
NemoClinics platform is hiring an engineer. Check out the opportunity here: U 1141 -Ingénieur-e en expérimentation et instrumentation biologiques- CDD 2023 Read more
Research program on CCHS
CCHS is a disease characterized by a congenital impairment of the central control of breathing, associated with dysfunctions of the autonomic nervous system (ANS) (Gallego, 2012). At birth, patients have severe and persistent hypoventilation during sleep and a...