NemoClinics : technology
Tools for in vivo phenotyping of newborn rodents (mice and rats) are pivotal to study animal models of paediatric diseases. To this aim, size and immaturity of newborn animals raise great technical difficulties. We constituted an engineering core (mechanical, electronics, optics, computer science) to develop new methods and devices, and make possible to detect and study early neurodevelopmental disorders in vivo. To date, our phenotyping capability has no equivalent in the world. .
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NeoVent
Innovative device for obstructive and central apnea detection in newborn mice, and intermittent positive pressure ventilation.
© NemoCLinics
Non invasive monitoring of vital functions at birth
NemoClinics designed an innovative and patented device to monitor vital functions in newborn mice and rats (PhysioPups). PhysioPups allows non-invasive and simultaneous recording of breathing, heart rate, ultrasonic vocalisations, body temperature and metabolism (O2 consumption). Four animals can be monitored simultaneously. Recording, storage and processing are fully automated.
The PhysioPups device opens the way to high throughput screening of genetically engineered rodents since birth, and testing of drug effects on main functions development.
This technology has already proven to be pivotal for genetic models study during the neonatal period
- Ventilatory response to hyperoxia in newborn mice heterozygous for the transcription factor Phox2b, Am J Physiol Regul Integr Comp Physiol. 2006.
- Effects of temperature on ventilatory response to hypercapnia in newborn mice heterozygous for transcription factor Phox2b, Am J Physiol Regul Integr Comp Physiol . 2007
- A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons, Proc Natl Acad Sci U S A. 2008
- Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism, Proc Natl Acad Sci U S A. 2008
- Cold stimulates the behavioral response to hypoxia in newborn mice, Am J Physiol Regul Integr Comp Physiol . 2009
- Systemic inflammation disrupts the developmental program of white matter, Ann Neurol. 2011
- Breathing without CO(2) chemosensitivity in conditional Phox2b mutants, J Neurosci. 2011
- Impaired ventilatory and thermoregulatory responses to hypoxic stress in newborn phox2b heterozygous knock-out mice, Front Physiol. 2011
- The vesicular glutamate transporter VGLUT3 contributes to protection against neonatal hypoxic stress, J Physiol. 2012
- Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice, Oncotarget. 2014
- Safety study of Ciprofloxacin in newborn mice, Regul Toxicol Pharmacol. 2016
- Acetylcholine Modulates the Hormones of the Growth Hormone/Insulinlike Growth Factor-1 Axis During Development in Mice, Endocrinology. 2018
- Myelination induction by a histamine H3 receptor antagonist in a mouse model of preterm white matter injury, Brain Behav Immun. 2018
- Breathing under Anesthesia: A Key Role for the Retrotrapezoid Nucleus Revealed by Conditional Phox2b Mutant Mice, Anesthesiology. 2019
Cognitive and sensorimotor testing
NemoClinics devised new methods of classical and operant conditioning for learning abilities evaluation (Bouslama, Durand et al. 2005; Bollen 2012). They have been applied to brain lesions models (Bouslama, Chauviere et al. 2006; Bouslama, Renaud et al. 2007). Automated tests with the MemoryPups device guarantees a high reproducibility of results.
Additionnaly, NemoClinics developed a new device integrating innovative lighting and video recording technologies (NeoGait). It allows full characterization and quantitative scoring of the postnatal stages of gait development in newborn rodent (crawling, pelvic lift, pivoting, coordinated gait). The device has already been used in a neurodevelopmental study (Dehorter, Michel et al. 2011).
NemoClinics also performs psychomotor tests known as the Fox Battery (Fox et al. 1965) during the first weeks of life and Digigait® evaluation in adult mice.
Research and development
NemoClinics is continuously working on innovative technologies for newborn rodents phenotyping, including:
- Thoraco-abdominal asynchrony
- Pneumotachography
- Neonatal resuscitation
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New Golgipathy identified in NeuroDev team
The NeuroDev team publishes an article in Life Science Alliance [1] identifying the first human pathogenic variant of GORASP1, the gene encoding the Golgi stacking protein GRASP65, and demonstrating its consequences on glycosylation and mitotic progression. [1] S....
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Post-doc opportunity (1-2 years) within the group “Mitochondria and NDD” in the NeuroDev team
POSITION DESCRIPTION Postdoctoral position in the field of Neurosciences Type of contract: temporary position (CDD) Contract/project period: 1-2 years Expected date of employment: 1.04.2025 Proportion of work: 100% Workplace: Université Paris Cité, Inserm,...
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Advancing psychiatry through Sleep and Chronobiology research
The “Mood” research axis of the SleepCmd team is dedicated to understanding the intricate links between sleep, circadian rhythms, and mood disorders such as depression, bipolar disorder, seasonal affective disorder, and suicide. Using state-of-the-art methods, the...
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Job opportunity within The Integrative Genomics in Neurodevelopment group
The Integrative Genomics in Neurodevelopment group is seeking a highly motivated post-doctoral researcher. Check out the opportunity here: Post-doc researcher position in Computational Biology